RESUMO
PURPOSE:To investigate the structural and functional changes induced by corticosterone (CORT) in the ventral prostrate (VP) of rats in order to study chronic stress effects in the prepubertal phase.METHODS:Wistar rats received daily saline or CORT injections during the pubertal period from the 5th to 25th day of postnatal life. The animals were distributed into four groups: 1 - Control (n=5); 2 - Control 99mTc-P (n=5); 3 - Treated with CORT (n=14); 4 - Treated with CORT and 99mTc-P (n=10). All rats were sacrificed at two months of age. Technical tissue uptakes of 99mTc-P were used to evaluate the functional and stereological methods for morphological analysis.RESULTS:Acini distribution in the group treated with CORT differed significantly (p 0.0001) from the control. The control group's epithelial average height (10.01±0.24 microns) was statistically significant (p 0.0001) from rats treated with CORT (19.27±0.73microns). The collagen distribution was lower in the treated group (2.79%) when compared to control (3.97%). The radioactivity percentage in the groups marked with 99mTc-P (%Ati/g) did not demonstrate a statistically significant difference (p=0.285897).CONCLUSION:Chronic administration of corticosterone in prepubertal rats causes changes in their acinar structure and their ventral prostate stroma, indicating possible deleterious effects of this hormone.
Assuntos
Masculino , Animais , Ratos , Corticosterona/efeitos adversos , Glucocorticoides , PróstataRESUMO
PURPOSE: To investigate the structural and functional changes induced by corticosterone (CORT) in the ventral prostrate (VP) of rats in order to study chronic stress effects in the prepubertal phase. METHODS: Wistar rats received daily saline or CORT injections during the pubertal period from the 5th to 25th day of postnatal life. The animals were distributed into four groups: 1 - Control (n=5); 2 - Control 99mTc-P (n=5); 3 - Treated with CORT (n=14); 4 - Treated with CORT and 99mTc-P (n=10). All rats were sacrificed at two months of age. Technical tissue uptakes of 99mTc-P were used to evaluate the functional and stereological methods for morphological analysis. RESULTS: Acini distribution in the group treated with CORT differed significantly (p<0.0001) from the control. The control group's epithelial average height (10.01±0.24 microns) was statistically significant (p<0.0001) from rats treated with CORT (19.27±0.73microns). The collagen distribution was lower in the treated group (2.79%) when compared to control (3.97%). The radioactivity percentage in the groups marked with 99mTc-P (%Ati/g) did not demonstrate a statistically significant difference (p=0.285897). CONCLUSION: Chronic administration of corticosterone in prepubertal rats causes changes in their acinar structure and their ventral prostate stroma, indicating possible deleterious effects of this hormone. .
Assuntos
Animais , Feminino , Masculino , Anti-Inflamatórios/efeitos adversos , Corticosterona/efeitos adversos , Próstata/efeitos dos fármacos , Estresse Psicológico/metabolismo , Fatores Etários , Células Acinares/efeitos dos fármacos , Colágeno/análise , Tamanho do Órgão/efeitos dos fármacos , Próstata , Ratos Wistar , Desenvolvimento Sexual , Fatores de TempoRESUMO
Los corticoides se unen a receptores citoplasmaticos para luego interactuar con el ADN nuclear para la sintesis del RNA mensajero y la produccion de proteinas efectoras de la accion de los corticoides. Producen disminucion Leucocitaria pero con aumento de los neutrofilos, con accion mas maracada sobre los Linfocitos T que sobre los B; mejoran la inflamacion por inhibicion de la Quimiotaxis celular asi como la produccion de Prostaglandianas y Leucotrienos. Los corticoides se prescriben de acuerdo con la via de administracion, potencia, cuadro clinico, dosis, tipo de dermatosis, etc. Se describen las Dermatiitis en las que se debe usar Corticoides asi como en las que su uso no esta indicado